trans‐1,3,3,3‐Tetrafluoropropene

MAK Value Documentation, addendum – Translation of the German version from 2019

  Andrea Hartwig¹
  MAK Commission<sup>2

1</sup> Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
² Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of trans‐1,3,3,3‐tetrafluoropropene [29118‐24‐9]. As the blood:air partition coefficient of trans‐1,3,3,3‐tetrafluoropropene is < 5, the increased respiratory volume at the workplace (see List of MAK and BAT Values, Sections I b and I c) does not have to be taken into account for the derivation of the MAK value. Even after extrapolation of 6‐hour exposure in the animal experiment to 8‐hour exposure at the workplace, the MAK value for trans‐1,3,3,3‐tetrafluoropropene of 1000 ml/m³ can be retained.

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