1. Publishing
    2. Series
    3. Overview
    4. MAK Collection
    5. The MAK Collection for Occupational Health and Safety
    6. Article
    7. Volume 3 (2018)
    8. Issue 4
    9. Addendum zu Ethylenglykoldinitrat. Beurteilungswerte in biologischem Material
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



Addendum zu Ethylenglykoldinitrat

Beurteilungswerte in biologischem Material

Katrin Klotz1
  Hans Drexler1 (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig2 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission3

1 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
2 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
3 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the biological tolerance value (BAT value) for ethylene glycol dinitrate [CAS No. 628‐96‐6] in 2017.

Aim of this re‐evaluation was the lowering of the MAK value from 0.05 to 0.01 mL/m³ (for the sum of ethylene glycol dinitrate, nitroglycerin and propylene glycol dinitrate). The former BAT value of 0.3 µg ethylene glycol dinitrate/L blood was based on a correlation between external and internal exposure to the former MAK value of 0.05 ml/m³. The limit of detection of the applied analytical method was 0.2 µg ethylene glycol dinitrate/L blood. Correlating values of ethylene glycol dinitrate to the present MAK value would result in values below the limit of detection. Further studies and more sensitive analytical methods are missing. Therefore, the BAT value was withdrawn.

Keywords

ethylene glycol dinitrate, biological tolerance value, BAT value