Aniline – Addendum: evaluation of a BAR
Assessment Values in Biological Material – Translation of the German version from 2026
Britta Brinkmann1Hans Drexler2 (Head of the working group “Assessment Values in Biological Material” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
Andrea Hartwig3 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
MAK Commission4
1 Project Management Agency Karlsruhe (PTKA), Secretariat of the MAK Commission, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
2 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Henkestraße 9–11, 91054 Erlangen, Germany
3 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
4 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) evaluated the data for aniline [62-53-3] to derive a biological reference value (BAR). The 95th percentiles of background concentrations in the urine of occupationally unexposed persons ranged between 6.5 and 14.5 µg aniline/l. Based on available studies, a weighted mean value of the 95th percentile of 13.3 µg aniline/l can be calculated. Therefore, a BAR of 15 µg aniline (after hydrolysis)/l urine has been derived for aniline. The BAR applies to both smokers and non-smokers, as the urine concentrations did not differ significantly. Sampling should take place at the end of exposure or at the end of the shift.
