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    7. Volume 11 (2026)
    8. Issue 1
    9. 1,3-Dichlorbenzol – Evaluierung eines Biologischen Leitwertes (BLW)
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



1,3-Dichlorbenzol – Evaluierung eines Biologischen Leitwertes (BLW)

Beurteilungswerte in biologischem Material

Andrea Kaifie1
Wobbeke Weistenhöfer1
Thomas Kraus2
  Hans Drexler1 (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig3 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission4

1 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
2 Institut für Arbeits-, Sozial- und Umweltmedizin, Uniklinik RWTH, Pauwelsstraße 30, 52074 Aachen, Deutschland
3 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
4 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

In 2025, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated a biological guidance value (BLW) for 1,3‑dichlorobenzene [541-73-1]. Relevant publications were identified from a literature search. For the derivation of the BLW, an experimental study was available that demonstrated a good correlation between the concentration of 1,3-dichlorobenzene in the air and 1,3-dichlorobenzene in blood as well as the urinary metabolites 3,5‑dichlorocatechol, 2,4‑dichlorophenol and 3,5-dichlorophenol. The data of the experimental study conducted with resting volunteers for 6-hours were extrapolated to account for an exposure of 8 hours and an increased respiratory volume at the work place. At the level of the MAK value of 2 ml/m3, an average value of 40 mg 3,5-dichlorocatechol (after hydrolysis)/g creatinine can be expected and was set as BLW. Sampling time is at the end of the shift, after several previous shifts.

Keywords

1,3-dichlorobenzene, 3,5-dichlorocatechol, biological guidance value, BLW