1. Publishing
    2. Series
    3. Overview
    4. MAK Collection
    5. The MAK Collection for Occupational Health and Safety
    6. Article
    7. Volume 9 (2024)
    8. Issue 4
    9. Beryllium und seine anorganischen Verbindungen – Addendum: Reevaluierung des BAR
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



Beryllium und seine anorganischen Verbindungen – Addendum: Reevaluierung des BAR

Beurteilungswerte in biologischem Material

Julia Hiller1
Wobbeke Weistenhöfer1
  Hans Drexler1 (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig2 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission3

1 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
2 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
3 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarised and re-evaluated the data for beryllium and its inorganic compounds regarding the recommended sampling times for biomonitoring, the derivation of exposure equivalents for carcinogenic substances (EKA) and the biological reference value (BAR) in urine. Only one new study reports data for beryllium in air and urine, but for the same beryllium concentration in air, the corresponding concentration in urine was lower than that given in two older publications. Considering the inconsistent data and questions on the validity of older analytical methods, the data base is not sufficient to derive EKA. The BAR was re-evaluated and a BAR of 0.02 µg/l urine was established based on the data for background exposure. Sampling should be conducted after a steady state has been reached. The data base is not sufficient for the evaluation of a BAR in blood.

Keywords

beryllium, biological reference value, BAR, exposure equivalents for carcinogenic substances, EKA