2-Diethylaminoethanol
MAK Value Documentation, addendum – Translation of the German version from 2022
Andrea Hartwig1 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
2 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) has re-evaluated the occupational exposure limit value (maximum concentration at the workplace, MAK value) and the pregnancy risk group of 2-diethylaminoethanol [100-37-8] considering also irritating and sensitizing effects. Relevant studies were identified from a literature search. The critical effect of 2-diethylaminoethanol is the local effect on the upper respiratory tract. There are no human data to derive a MAK value. In a 14-week inhalation study with rats already reported in the evaluation from 2007, the lowest concentration of 11 ml/m3 is the NOAEC resulting in a MAK value of 2 ml/m3. Since a local effect is critical, Peak Limitation Category I is retained. As data on humans are missing, an excursion factor of 1 and in analogy to other amines with a MAK value of 2 ml/m3, a momentary value of 5 ml/m3 is set. In a developmental toxicity study in rats reported in the evaluation from 2007, the highest concentration of 100 ml 2-diethylaminoethanol/m3 corresponds to the NOAEC. There are no new data on developmental toxicity. Considering the increased respiratory volume at the workplace there is a 25-fold margin to the MAK value. Thus, Pregnancy Risk Group C has been retained for 2-diethylaminoethanol. There are no data showing a skin sensitizing potential in humans or animals. Data investi-gating respiratory sensitization are missing. According to skin absorption models, 2-diethylaminoethanol is not expected to be taken up via the skin in toxicologically relevant amounts and is thus no longer designated with “H”.
