Indium und seine anorganischen Verbindungen – Evaluierung von Beurteilungswerten in biologischem Material

Beurteilungswerte in biologischem Material

Bernhard Michalke¹
  Hans Drexler² (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig³ (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission<sup>4

1</sup> Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Abteilung Analytische BioGeoChemie, Ingolstädter Landstraße 1, 85764 Neuherberg, Deutschland
² Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
³ Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
⁴ Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and evaluated the data for indium [7440-74-6] and its inorganic compounds to derive a biological guidance value (BLW) or a biological reference value (BAR) considering all toxicological end points. Relevant studies were identified from a literature search. Herein, background concentrations in serum of control sample donors were compared with those of exposed workers. Only one publication reported values in urine aside from serum values, both showing no correlation to indium concentrations in air. None of the studies detected any relationship between external and internal exposure. It was also not possible to derive a concentration at which toxicity occurs. Background concentrations reported in several studies overlapped with the serum indium concentrations from other studies of exposed subjects having already significant adverse effects. An explanation cannot be deduced from the available data. The relevant concentrations furthermore are very low, meaning that laboratories have to work close to their limits of quantitation, which consequently leads to a high error scattering. Accordingly, no BLW and no BAR could be derived.

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