2-Ethylhexyl oleate
MAK Value Documentation – Translation of the German version from 2022
Andrea Hartwig1 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
2 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and evaluated the data for 2-ethylhexyl oleate [26399-02-0] to derive an occupational exposure limit value (maximum concentration at the workplace, MAK value), considering all toxicological end points. Available publications are described in detail. As with white mineral oil, inhalation of aerosols of the hardly water-soluble 2-ethylhexyl oleate could result in overload in the lung, inflammatory reactions and microgranulomas. To prevent this overload, a MAK value of 5 mg/m3 for the respirable fraction is established by analogy with white mineral oil and Peak Limitation Category II as well as an excursion factor of 4 is set. The substance is classified in Pregnancy Risk Group D because developmental toxicity studies are lacking. 2-Ethylhexyl oleate is not genotoxic. Carcinogenicity studies are not available. There are no indications of a sensitizing potential of 2-ethylhexyl oleate. Skin contact is not expected to contribute significantly to systemic toxicity.
