Addendum zu Molybdän und seine Verbindungen
Beurteilungswerte in biologischem Material
Bernhard Michalke1Hans Drexler2
Andrea Hartwig3
MAK Commission4
1 Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Abteilung Analytische BioGeoChemie, Ingolstädter Landstraße 1, 85764 Neuherberg, Deutschland
2 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
3 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
4 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
In 2018, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated Molybdenum and its compounds. Available publications are described in detail.
In recent publications since the last evaluation in 2005 some authors investigated Molybdenum concentrations in blood or urine with respect to occupational Molybdenum exposure, however, without a conclusive outcome: The results of the different studies were either contradictory or missed respective exposure data and/or quality control measures. Therefore, no BAT value (biological tolerance value) was derived. However, some studies reported background concentrations in men, women or children, most of them with sufficiently applied quality control. In these studies, it was found that nutrition is the most important contribution to Molybdenum in urine. Several studies with quality control means and with sufficient statistical power revealed similar concentration ranges between 34–50 µg/l urine and/or 95% percentiles around 150 µg/l urine. In conclusion, a BAR of 150 µg Molybdenum/l urine was derived.
