1. Publishing
    2. Series
    3. Overview
    4. MAK Collection
    5. The MAK Collection for Occupational Health and Safety
    6. Article
    7. Volume 9 (2024)
    8. Issue 1
    9. Methoxyessigsäure – Evaluierung des BAT-Wertes
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



Methoxyessigsäure – Evaluierung des BAT-Wertes

Beurteilungswerte in biologischem Material

Thomas Göen1
  Hans Drexler1 (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig2 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission3

1 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
2 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
3 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and evaluated the data for methoxyacetic acid [625-45-6] to derive a biological tolerance value (BAT value) considering all toxicological end points. There are no toxicological data from humans occupationally exposed to methoxyacetic acid. For methoxyethanol, a substance which is efficiently metabolised to the toxic methoxyacetic acid, many human studies provide sufficient toxicological data as well as toxicokinetic information on the metabolite. A BAT value of 15 mg methoxyacetic acid/g creatinine was derived for 2-methoxyethanol based on the haematotoxic effects in occupationally exposed individuals in 2008. The BAT value was confirmed in 2023. As a result, the BAT value of 15 mg methoxyacetic acid/g creatinine was likewise derived for exposure to methoxyacetic acid. Sampling time is at the end of the shift on the last day of the working week after at least 2 weeks of exposure.

Keywords

methoxyacetic acid, biological tolerance value, BAT value