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    6. Article
    7. Volume 3 (2018)
    8. Issue 4
    9. Addendum zu Aluminium. Beurteilungswerte in biologischem Material
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



Addendum zu Aluminium

Beurteilungswerte in biologischem Material

Katrin Klotz1
Monika Meyer‐Baron2
Christoph van Thriel2
Dirk Pallapies3
Michael Nasterlack4
Stephan Letzel5
Bernd Roßbach5
Gerhard Triebig6
Wobbeke Weistenhöfer1
  Hans Drexler1 (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig7 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission8

1 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
2 Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Ardeystraße 67, 44139 Dortmund, Deutschland
3 Institut für Prävention und Arbeitsmedizin der DGUV, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Deutschland
4 68526 Ladenburg, Deutschland
5 Institut für Arbeits-, Sozial- und Umweltmedizin, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Obere Zahlbacher Straße 67, 55131 Mainz, Deutschland
6 74915 Waibstadt, Deutschland
7 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
8 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the biological tolerance value (BAT value) for aluminium [CAS No. 7429‐90‐5] in 2017. Available publications are described in detail.

The BAT value of 60 µg aluminium/g creatinine evaluated in 2009 was based on the linear correlation between external and internal exposure. Aim of this re‐evaluation was the derivation of a health‐based BAT value considering the most sensitive critical effect of aluminium, the neurotoxicity. For this purpose, the available studies of aluminium‐exposed workers were taken into account, when the internal aluminium exposure as well as the occurrence of subclinical neurotoxic effects were determined. The effects had been measured with standardised neuropsychological test procedures. From these studies, a no observed adverse effect level (NOAEL) of 50 µg/g creatinine for the occurrence of subtle neurotoxic effects of humans was estimated. Therefore, a BAT value of 50 µg aluminium/g creatinine was evaluated. Sampling time for long‐term exposures is at the end of the shift after several shifts.

Keywords

aluminium, biological tolerance value, BAT value, neurotoxicity