Allylpropyldisulfid
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) has re-evaluated the data for allyl propyl disulfide [2179-59-1] with regard to its occupational exposure limit value (maximum concentration at the workplace, MAK value) and all other toxicological end points. Relevant studies were identified from a literature search. Allyl propyl disulfide causes irritation of the eyes, nose and throat in humans. There are no new data on irritation relevant for evaluation. As the previous derivation of the MAK value for allyl propyl disulfide does not correspond to the current procedure of the Commission, the MAK value and the peak limitation are suspended and the substance is listed in the Section II b of the List of MAK and BAT Values. Allyl propyl disulfide is not mutagenic in Salmonella typhimurium and there are no indications of an independent sensitizing effect. Skin contact is not expected to contribute significantly to systemic toxicity. Data on developmental toxicity, carcinogenicity and germ cell mutagenicity are not available.
