Glutarsäure
MAK-Begründung
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated glutaric acid [110‐94‐1] considering all toxicological endpoints. Available publications and unpublished study reports are described in detail.
The critical effect is a moderate local irritation as shown with the Draize test in the rabbit eye. Inhalation studies are not available. Systemic toxicity occurs only at high doses. 500 and 1800 mg/kg body weight and day, respectively. The lowest systemic NOAEL is 250 mg/kg body weight and day for dogs, which corresponds to a concentration of 146 mg/m3 at the workplace.
To prevent irritation, a maximum concentration at the workplace (MAK value) of 2 mg/m3 is derived for the respirable fraction by analogy with phosphoric acid and adipic acid and the substance is classified in Peak Limitation Category I with an excursion factor of 2.
Glutaric acid is not genotoxic and carcinogenicity studies are not available. After toxicokinetic scaling, the NOAELs from oral developmental toxicity studies in rats and rabbits correspond to concentrations of 2275 mg/m3 and 1458 mg/m3, respectively. Therefore, damage to the embryo or foetus is unlikely when the MAK value is not exceeded and glutaric acid is classified in Pregnancy Risk Group C. Skin contact is not expected to contribute significantly to systemic toxicity. Limited data show no sensitization.
