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    9. 2‐Methoxypropanol‐1. MAK Value Documentation, addendum – Translation of the German version from 2018
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



2‐Methoxypropanol‐1

MAK Value Documentation, addendum – Translation of the German version from 2018

  Andrea Hartwig1 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
  MAK Commission2

1 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
2 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for 2‐methoxypropanol‐1 [1589‐47‐5]. Available publications and unpublished study reports are described in detail.

Critical effects of 2‐methoxypropanol‐1 are its irritancy and teratogenicity. A MAK value of 5 ml/m3 had been set. By analogy with 2‐methoxypropylacetate‐1, this value is now reaffirmed.

Also, by analogy with 2‐methoxypropylacetate‐1 Peak Limitation Category I with excursion factor of 2 is set. 2‐Methoxypropanol‐1 remains assigned to Pregnancy Risk Group B and also remains designated with an “H” (for substances that can be absorbed through the skin in toxicologically relevant amounts).

Keywords

2-methoxypropanol-1, maximum workplace concentration, MAK value, peak limitation, irritation, teratogenicity, developmental toxicity, skin absorption