Parathion – Addendum: withdrawal of the BAT value for acetylcholinesterase inhibitors and continuation as BLW, withdrawal of the BAT value for p-nitrophenol in urine
Assessment Values in Biological Material – Translation of the German version from 2024
Wobbeke Weistenhöfer1Hans Drexler2 (Head of the working group “Assessment Values in Biological Material” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
Andrea Hartwig3 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
MAK Commission4
1 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Henkestraße 9–11, 91054 Erlangen, Germany
2 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Henkestraße 9–11, 91054 Erlangen, Germany
3 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
4 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) decided to suspend the maximum concentration at the workplace (MAK value) and the other classifications of the insecticide and acaricide parathion [56-38-2], because it is no longer approved in the European Union and previous MAK value documentation and supplements do not reflect current data for the substance. As a new evaluation is not of high priority, the substance is listed in Section II c of the List of MAK and BAT Values for substances no longer evaluated. The biological tolerance value (BAT value) for parathion, for the parameter p-nitrophenol in urine, was set in correlation to the former MAK value and was therefore withdrawn. The biological guidance value (BLW) (formerly BAT value) of “reduction of acetylcholinesterase activity to 70% of the reference value” still remains.
