Bis[O,O-bis(2-ethylhexyl) dithiophosphorato-S,S′]dioxodi-µ-thioxodimolybdenum

MAK Value Documentation – Translation of the German version from 2022

  Andrea Hartwig¹ (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
  MAK Commission<sup>2

1</sup> Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
² Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany

Abstract

The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and evaluated the data for bis[O,O-bis(2-ethylhexyl) dithiophosphorato-S,Sʹ]dioxodi-μ-thioxodimolybdenum [68958-92-9; 72030-25-2] to derive an occupational exposure limit value (maximum concentration at the workplace, MAK value) considering all toxicological end points. The documentation is based primarily on the REACH registration dossier. A study described in the REACH registration dossier that was carried out according to OECD Test Guideline 422 found increased kidney weights in male rats and elevated levels of thyroid-stimulating hormone in female rats at 100 mg/kg body weight and day. As the percentage change in kidney weights was not specified and the study was not made available to the Commission, a maximum concentration at the workplace (MAK value) cannot be derived and bis[O,O-bis(2-ethylhexyl) dithiophosphorato-S,Sʹ]dioxodi-μ-thioxodimolybdenum has been assigned to Section II b of the List of MAK and BAT Values. Bis[O,O-bis(2-ethylhexyl) dithiophosphorato-S,Sʹ]dioxodi-μ-thioxodimolybdenum was not found to be genotoxic in vitro; neither in vivo genotoxicity data nor carcinogenicity studies are available. There is no clear evidence of a contact sensitizing potential and no data for sensitization of the respiratory tract. Bis[O,O-bis(2-ethylhexyl) dithiophosphorato-S,Sʹ]dioxodi-μ-thioxodimolybdenum is not expected to be taken up via the skin in toxicologically relevant amounts.

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