2-Methoxyethanol, 2-Methoxyethylacetat, Methoxyessigsäure, Diethylenglykoldimethylether, Diethylenglykolmonomethylether – Addendum: Evaluierung einer Schwangerschaftsgruppe zu den BAT-Werten mit dem Parameter Methoxyessigsäure
Beurteilungswerte in biologischem Material
Sandra Michaelsen1Rüdiger Bartsch1
Britta Brinkmann1
Gerlinde Schriever-Schwemmer1
Hans Drexler2 (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
MAK Commission3
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
3 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and evaluated the data for prenatal toxicity and derived a methoxyacetic acid concentration in urine at which damage to the embryo or foetus is unlikely (“prerequisite for Pregnancy Risk Group C”) for 2-methoxyethanol [109-86-4], 2-methoxyethyl acetate [110-49-6], methoxyacetic acid [625-45-6], diethylene glycol dimethyl ether [111-96-6], and diethylene glycol monomethyl ether [111-77-3]. These substances are classified in Pregnancy Risk Group B because adhering to the biological tolerance value (BAT value) of 15 mg methoxyacetic acid/g creatinine cannot exclude a risk to the developing foetus. This classification was based on embryo-/foetotoxic and teratogenic effects in rats, mice, rabbits and monkeys. The effects are caused by methoxyacetic acid, the metabolite of all substances. From the lowest NOAEC (no observed adverse effect concentration) for developmental toxicity in rabbits of 3 ml 2-methoxyethanol/m3, a concentration of 0.15 ml 2-methoxyethanol/m3 at the workplace was derived for which damage to the embryo or foetus is unlikely. This external concentration corresponds to a urine concentration of 2.5 mg methoxyacetic acid/g creatinine. Therefore, an internal exposure not higher than this concentration would be the prerequisite for an assignment to Pregnancy Risk Group C.
