Fettalkohole C12–18
MAK-Begründung
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and evaluated the data for fatty alcohols C12–18 [67762-25-8] to derive an occupational exposure limit value (maximum concentration at the workplace, MAK value) considering all toxicological end points. Relevant studies were identified from a literature search. There are no data for humans or repeated dose inhalation studies in animals to derive a MAK value for the fatty alcohols C12–18. Oral studies investigating alcohols with similar chain length resulted in NOAELs which would correspond to a concentration of 92 mg/m3 or higher at the workplace. However, as the fatty alcohols C12–18 may act as non-ionic surfactants, effects on the pulmonary surfactant are likely to occur. As a result, a MAK value cannot be established. The fatty alcohols C12–18 are not mutagenic or clastogenic in vitro. No in vivo genotoxicity studies and no carcinogenicity studies have been carried out with the fatty alcohols C12–18. There are no studies investigating the developmental toxicity of the fatty alcohols C12–18. A sensitizing potential is not expected based on the available data. The substance does not penetrate the skin in toxicologically relevant amounts.
