p-Chloroaniline – Determination of p-chloroaniline in workplace air using gas chromatography (GC-MS)

Air Monitoring Method

Ralf Schmitt¹ (Method development)
  Thomas Helmut Brock² (Head of the working group “Analytics”)
  Ralph Hebisch³ (Head of the working group “Air Analyses” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig⁴ (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
  MAK Commission<sup>5

1</sup> BASF SE, Carl-Bosch-Straße 38, 67056 Ludwigshafen, Germany
² German Social Accident Insurance, Institution for the raw materials and chemical industry, Prevention - Department of Hazardous Substances, Biological Agents and Analytical Chemistry, Kurfürsten-Anlage 62, 69115 Heidelberg, Germany
³ Federal Institute for Occupational Safety and Health (BAuA), Friedrich-Henkel-Weg 1–25, 44149 Dortmund, Germany
⁴ Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
⁵ Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany

Abstract

This analytical method is a validated measurement procedure for the determination of p-chloroaniline [106-47-8] after personal or stationary sampling. Sampling is performed by drawing a defined volume of air through two acid-impregnated glass fibre filters using a suitable flow-regulated pump. After liquid desorption, the p-chloroaniline retained on the filters is analysed using gas chromatography with mass spectrometry. The relative limit of quantification is 0.0037 mg/m³ for an air sample volume of 240 l. The mean recovery for p-chloroaniline is 99.9%. The concentration-dependent expanded uncertainty is at most 27%. This analytical method has been accredited by the accident insurance companies for the detection in workplace air of substances that are carcinogenic, mutagenic or toxic to reproduction. This method has been tested and recommended for the determination of p-chloroaniline in work areas by the German Social Accident Insurance (DGUV). Both personal and stationary sampling can be performed for measurements in order to evaluate work areas.

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