Addendum to Ethylene glycol dinitrate
Assessment Values in Biological Material – Translation of the German version from 2018
Katrin Klotz1Hans Drexler1
Andrea Hartwig2
MAK Commission3
1 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Henkestraße 9–11, 91054 Erlangen, Germany
2 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
3 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the biological tolerance value (BAT value) for ethylene glycol dinitrate [CAS No. 628‐96‐6] in 2017.
Aim of this re‐evaluation was the lowering of the MAK value from 0.05 to 0.01 ml/m3 (for the sum of ethylene glycol dinitrate, nitroglycerin and propylene glycol dinitrate). The former BAT value of 0.3 µg ethylene glycol dinitrate/l blood was based on a correlation between external and internal exposure to the former MAK value of 0.05 ml/m3. The limit of detection of the applied analytical method was 0.2 µg ethylene glycol dinitrate/l blood. Correlating values of ethylene glycol dinitrate to the present MAK value would result in values below the limit of detection. Further studies and more sensitive analytical methods are missing. Therefore, the BAT value was withdrawn.
