2‐Methoxypropylacetate‐1
MAK Value Documentation, addendum – Translation of the German version from 2018
Andrea Hartwig1MAK Commission2
1 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
2 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for 2‐methoxypropylacetate‐1 [70657‐70‐4]. Available publications and unpublished study reports are described in detail.
Critical effects of 2‐methoxypropylacetate‐1 are its irritancy and teratogenicity. A MAK value of 5 ml/m3 had been set. This value is now reaffirmed based on the findings on the irritancy of the substance in a 28‐day inhalation study with rats.
Since a local effect is critical, Peak Limitation Category I with excursion factor of 2 has been set. 2‐Methoxypropylacetate‐1 remains assigned to Pregnancy Risk Group B and it also remains designated with an “H” (for substances that can be absorbed through the skin in toxicologically relevant amounts).
