2,3‐Pentanedione – Method for the determination of 2,3‐pentanedione in workplace air using gas chromatography‐mass spectrometry (GC‐MS)
Air Monitoring Method – Translation of the German version from 2017
Claudia Schuh1 (Method development)Lutz Nitschke2 (External verification)
Ralph Hebisch3 (Head of the working group “Air Analyses” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
Thomas Helmut Brock4 (Head of the working group “Analytics”)
Andrea Hartwig5 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
MAK Commission6
1 German Social Accident Insurance Institution for the foodstuffs industry and the catering trade, Dynamostraße 7–11, 68165 Mannheim, Germany
2 Bavarian Health and Food Safety Authority, Pfarrstraße 3, 80538 München, Germany
3 Federal Institute for Occupational Safety and Health (BAuA), Friedrich-Henkel-Weg 1–25, 44149 Dortmund, Germany
4 German Social Accident Insurance, Institution for the raw materials and chemical industry, Prevention - Department of Hazardous Substances, Biological Agents and Analytical Chemistry, Kurfürsten-Anlage 62, 69115 Heidelberg, Germany
5 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
6 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
This analytical method is a validated measurement procedure for the determination of 2,3‐pentanedione in workplace air in a concentration range of a tenth up to twice the currently valid MAK value of 0,083 mg/m3. Sampling is performed by drawing a defined volume of air through a silica gel tube using a suitable flow‐regulated pump. The flow rate is set to 0.33 L/min with a recommended air sample volume of approx. 20 L at a sampling time of 1 hour. For sampling 1 hour or 15 min (checking the short‐term value) can be used. The collected 2,3‐pentanedione is desorbed with acetone containing the internal standard cyclohexanone and then analysed by means of gas chromatography‐mass spectrometry (GC‐MS). The quantitative evaluation is based on a calibration function obtained by means of a 10‐point calibration using cyclohexanone as internal standard. The limit of quantification is 0.0025 mg/m3 based on an air sample volume of approx. 20 L or 0.010 mg/m3 based on an air sample volume of approx. 5 L (for short‐term value).
Joint Publication of the Analytical Subcommittee of the Chemistry Board of Experts of the Expert Committee Raw Materials and Chemical Industry of the German Social Accident Insurance and the working group “Air Analyses” of the Permanent Senate Commission of the DFG for the Investigation of Health Hazards of Chemical Compounds in the Work Area.
