Acetoin
MAK-Begründung
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and evaluated the data for acetoin [513-86-0] to derive an occupational exposure limit value (maximum concentration at the workplace, MAK value) considering all toxicological end points. Relevant studies were identified from a literature search. A NOAEC of 400 ml/m3 for inflammatory effects induced by acetoin in the respiratory tract was obtained from a study with 3-month inhalation exposure of rats. To prevent these inflammatory effects, a MAK value of 50 ml/m3 has been derived for acetoin and the substance has been assigned to Peak Limitation Category II with an excursion factor of 2. There are no prenatal developmental toxicity studies of acetoin. Therefore, acetoin has been assigned to Pregnancy Risk Group D. The substance is not genotoxic in vitro and in vivo. A long-term carcinogenicity study has not been performed. According to skin absorption models, percutaneous absorption is expected to contribute significantly to systemic toxicity. Therefore, acetoin has been designated with “H”. A sensitizing potential is not expected based on the data available.
