Acetylaceton (2,4‐Pentandion)
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of acetylacetone [123‐54‐6].
The critical effects are haematotoxicity, neurotoxicity and irritation of the nasal mucosa. A LOAEC of 307 ml/m3 for minimal effects on the blood and reduced body weight was obtained in a 14‐week inhalation study in the rat. A MAK value of 20 ml/m3 had been set. This value has now been confirmed even considering the increased respiratory volume at the workplace (see List of MAK and BAT Values, Section I b and I c). As a systemic effect is critical, Peak Limitation Category II with an excursion factor of 2 has been confirmed.
In spite of the low margin between the NOAEC for foetal toxicity of 53 ml/m3 and the MAK value, acetylacetone had been assigned to Pregnancy Risk Group C because the incidence of unspecific foetal toxicity was very low at the LOAEC of 202 ml/m3. This classification is retained even considering the increased respiratory volume at the workplace.
