Decaboran
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) has re-evaluated the data for decaborane [17702-41-9] considering all toxicological end points. Relevant studies were identified from a literature search. Decaborane is a highly toxic substance for which limited toxicological data are available. Accidental exposure of humans resulted in effects on the nervous system such as headaches, tremor, impaired coordination, confusion, anxiety, photophobia and other symptoms. Repeated inhalation studies in animals found lethality at the lowest concentration tested of 0.05 ml/m3 after continuous exposure for 90 days or at 4.5 ml/m3 after intermittent exposure for up to 6 months. Data suitable for deriving an occupational exposure limit value (maximum concentration at the workplace, MAK value) are not available. Therefore, decaborane has been listed in Section II b of the List of MAK and BAT Values. Dermal exposure of rabbits to 10 mg/kg body weight was lethal within 7 days. Decaborane remains designated with an “H” (for substances which can be absorbed through the skin in toxicologically relevant amounts). There are no data available to evaluate the sensitizing, genotoxic, carcinogenic or reproductive toxic effects of decaborane.
