Tri‐n‐butyl phosphate
Assessment Values in Biological Material – Translation of the German version from 2018
Elke Ochsmann1Wobbeke Weistenhöfer2
Katrin Klotz2
Hans Drexler2
Andrea Hartwig3
MAK Commission4
1 University Hospital Schleswig‐Holstein, Institute of Occupational Medicine, Prevention and Occupational Health Management, Ratzeburger Allee 160, 23562 Lübeck, Germany
2 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Henkestraße 9–11, 91054 Erlangen, Germany
3 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
4 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area evaluated tri‐n‐butyl phosphate [CAS No.126‐73‐8] in 2016 and derived a biological reference value (“Biologischer Arbeitsstoff‐Referenzwert”, BAR) for dibutyl phosphate in urine. Available publications are described in detail.
In a study with persons of the general population occupationally not exposed to tri‐n‐butyl phosphate a 95th percentile of 0.67 µg dibutyl phosphate/l urine was measured. Further studies with non‐exposed individuals resulted in maximum levels of 0.45 µg and 0.26 µg dibutyl phosphate/l urine.
Taking these results together with other investigations into consideration, a BAR for tri‐n‐butyl phosphate of 0.5 µg dibutyl phosphate/l urine was established. Sampling time is at the end of exposure or the end of the working shift.
