Cyclohexylamine
MAK Value Documentation, addendum – Translation of the German version from 2017
Andrea Hartwig1 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
2 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for cyclohexylamine.
A 4‐hour inhalation study with volunteers showed clear irritation at 10 ml/m3, whereas a time‐weighted average concentration of 2 ml/m3 with peaks of up to 4 ml/m3 was without impact on sensory irritation parameters and neurobehavioral measurements. The MAK value of 2 ml/m3 and classification in Peak Limitation Category I has been retained. No irritation was observed up to 4 ml/m3; therefore, the excursion factor 2 has been retained as well. As cyclohexylamine is a strong base and 10 ml/m3 is clearly irritating, a momentary value of 5 ml/m3 is set.
Completed: April 20, 2016
