Decahydronaphthalin
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for decahydronaphthalene [91‐17‐8].
Critical effect is kidney toxicity which is observed as increased activity of urinary lactate dehydrogenase (LDH) in a 14‐week inhalation study with rats beginning at the lowest concentration of 25 ml/m3 with a lower confidence limit of the benchmark dose (BMDL) of 12 ml/m3. A MAK value of 5 ml/m3 has been set. This value is now reaffirmed even considering the increased respiratory volume at the workplace (see List of MAK and BAT values, chapters I b and I c).
As there is no new data, Peak Limitation Category II with excursion factor of 2 is retained and decahydronaphthalene remains assigned to Pregnancy Risk Group D.
