Anilin
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for aniline [62‐53‐3]. Available publications and unpublished study reports are described in detail.
Healthy male and female volunteers showed increased methemoglobin values in a 6‐hour‐inhalation‐study with exposure to 2 ml aniline/m3. The median methemoglobin augmentation was 0.5 % from the base level of 0.7 % to 1.2 % methemoglobin. Even taking into account the highest observed increase of methemoglobin, 8 hour‐exposure time and the increased respiratory volume at the workplace, a methemoglobin value of more than 5 % would not be expected. Based on this, the MAK value for aniline of 2 ml/m3 (7.7 mg/m3) is confirmed. Aniline is still assigned to Peak Limitation Category II, because systemic effects are critical and the excursion factor of 2 is confirmed. Skin contact is expected to contribute significantly to the systemic toxicity. Therefore, the designation with an “H” is confirmed. Aniline continues to be designated with “Sh” and assigned to Carcinogenicity Category 4.
