25rg26
10.3205/25rg26
urn:nbn:de:0183-25rg261
Meeting Abstract
Proton beam therapy with endoresection as a vision-preserving option in advanced uveal melanoma
zur Bonsen
Bonsen
Lynn
L
Berlin
author
ten Hagen
ten Hagen
A.
A
Berlin
author
Vaghefi
Vaghefi
S. Ashraf
SA
Berlin
author
Knecht
Knecht
V.A.
VA
Berlin
author
Freisberg
Freisberg
L.
L
Berlin
author
Zeitz
Zeitz
O.
O
Berlin
author
Joussen
Joussen
A.M.
AM
Berlin
author
German Medical Science GMS Publishing House
Düsseldorf
610
20250613
engl
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung).
M0622
26
Retinologische Gesellschaft
37. Jahrestagung der Retinologischen Gesellschaft
Endophthalmitis/Tumor
Berlin
20250627
20250628
25rg26
TextIntroduction: Uveal melanoma is a rare but aggressive ocular malignancy. Treatment options for advanced cases include eye-preserving approaches such as proton beam therapy combined with endoresection and enucleation. This study presents a monocentric analysis of patients treated with endoresection for eye preservation.Methods: A total of 68 patients with uveal melanoma, presenting between January 2022 and December 2023, were analyzed. Tumor stages, the mean extent of tumor involvement in clock hours, exudative retinal detachment and visual outcomes were assessed. The visual acuity was evaluated at baseline and after 12 months.Results: Among the 68 patients receiving proton beam therapy with endoresection afterwards, the average tumor thickness was 9.9 mm. The most common tumor stages were IIB (n=35), IIIA (n=18), and IIA (10). The average age was 53 years [range: 21–82]. The mean tumor involvement was 3.9±0.9 clock hours, with an initial mean visual acuity of 0.6±0.7 LogMAR. Exudative retinal detachment was present in 58 patients. 12 months post-treatment, the average visual acuity remained at 1.0±0.6 LogMAR. Two patients required secondary enucleation.Conclusion: This study provides valuable insights into treatment options for advanced uveal melanoma. Especially for younger patients, proton beam therapy followed by endoresection may offer a vision-preserving alternative to enucleation.
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